美科学家发现抗癌药物flavopiridol可用来治疗AIDS
Flavopiridol是美国Aventis公司生产的一种mRNA转录抑制剂。该药物在临床上主要用于抗癌治疗，目前已进入Ⅱ期临床试验阶段。
Flavopiridol是目前最有效的P-TEFb酶抑制剂，后者在mRNA的转录过程中起着重要的作用。Flavopiridol正是通过对P-TEFb酶的抑制而产生其抗癌作用的。
由于P-TEFb酶对于HIV-1病毒的蛋白质合成（mRNA转录）同样至关重要，所以作为一种mRNA转录抑制剂，Flavopiridol亦能够有效地遏制HIV-1病毒的复制。
在实验中，科学家们发现，由于Flavopiridol对P-TEFb酶具有高度的抑制力，很小剂量的Flavopiridol即能对HIV-1病毒产生极强的杀伤力。这就意味着虽然Flavopiridol作用的对象是一种所有人体细胞中普遍存在的生物过程，但由于其所需的药用剂量很小，所以其在日后的临床应用中对人体正常细胞产生的影响并不会很大。
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